Friedländer Lab

Read the research highlight from our latest study to detect miRNA-target interaction in single cells was published on SciLiifeLab news site. Read the complete study here.

agoTRIBE overcomes the limitations of current techniques by enabling the identification of direct microRNA-target interactions in single cells, effectively providing a comprehensive profile of the target transcriptome on a single-cell scale. Read full research here

Our latest groundbreaking research, which sheds light on 130-year-old RNA molecules extracted from the extinct Tasmanian tiger, has garnered extensive coverage across multiple news platforms. Explore the news articles below to delve into the exciting findings:

CNN news: here ; Nature News: here ; Reuters: here ; Science News: here ; SU news: here

Read the research article here.

In our groundbreaking latest study, we have uncovered the hidden secrets of ancient RNA molecules within a preserved Tasmanian tiger specimen. This collaboration between SciLifeLab and the Centre for Palaeogenetics (CPG) at Stockholm University offers vital insights into extinct species’ transcriptomes, with implications for species resurrection and pandemic RNA virus research.

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Marc Friedländer has been awarded a consolidator grant from the Swedish Research Council (Vetenskapsrådet) for the project “Intrinsic synchronization of gene activity”. This will enable our research in single-cell biology for the next five years!

https://www.su.se/english/news/three-large-vr-grants-awarded-to-researchers-at-stockholm-university-1.638205

You can now watch the seminar recording here and read the full research here.

We are grateful for the generous grant from Cancerfonden – which will fund our efforts to discover cancer-specific microRNAs that are not present in healthy tissues. Such microRNAs could arise from perturbed cellular states and would be ideal biomarkers and drug targets. The grant will cover a new PhD position (see our JOIN US section)!

This study used a screening approach to measure microRNA biogenesis of >10,000 RNA structures in living cells and complemented with studying microRNA expression in hundreds of tissues from 20 animal species from MirGeneDB. It was conducted in collaboration with the Fromm lab and the GOLD lab. Read the full study here.

We are seeking a highly motivated and enthusiastic master’s student to join the team for a 4-months research internship (ECTS or paid) starting September 2021. 

The focus of this research project is to study novel microRNA-mediated functions in single cells by implementing an innovative single-cell protein and RNA co-profiling technique. Under close supervision by a postdoctoral researcher, the student will apply several molecular biology techniques such as proximity extension assay (PEA), microfluidic cell sorting, antibody conjugation, PCR, electrophoresis and RNA sequencing. Experience in molecular and cellular biology are required, with possibility in gaining insight into bioinformatics sequencing analysis. Finally, successful contribution to the project would be acknowledged as co-authorship on a research publication.

If you are interested in joining an international team of ambitious and friendly scientists, please send your CV and motivation letter describing your background and research interest to Marc Friedländer (marc.friedlander@scilifelab.se).

Update: this position is no longer available.

The Friedländer lab is welcoming summer in Stockholm and celebrating that our senior scientist Bastian has landed a very attractive (tenure-track and start-up) group leader position in Tromsø, Norway.

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