Mika and Kavan accomplished excellent work and defended their Master projects in the frame of the SciLifeLab Master’s programme in Molecular Techniques in Life Science (KI/KTH/SU). Our hearty congratulations to Mika and Kavan!
Starting in April, Laura Stanicek will join us as a postdoctoral fellow. She will be heading up the development of combined quantitative single cell proteomics and transcriptomics.
Mika and Kavan will be starting new scientific adventures in our group as they pursue the SciLifeLab Master’s programme in Molecular Techniques in Life Science (KI/KTH/SU) this spring.
Wenjing presents miRTrace selected for this year’s SciLifeLab Scientific Highlights.
Today we publish a comprehensive yet brief video tutorial on installation and usage of miRTrace – our quality control and taxonomic tracing software published in Genome Biology last year.
Under the lead of Bastian Fromm from the Friedlander lab, and in collaboration with a large international consortium, a new gold-standard for microRNA annotations, nomenclature and discovery was published with Nucleic Acids Research.
Abstract: MicroRNAs have gained substantial attention due to their roles in animal development and human disorders. Unique and mechanistically well understood features can clearly distinguish bona fide miRNAs from the myriad other small RNAs generated by cells. However, making this distinction is not a common practice and, thus, not surprisingly, the heterogeneous quality of available miRNA complements has become a major concern in microRNA research. We addressed this by extensively expanding our curated microRNA gene database – MirGeneDB – to 45 organisms, encompassing a wide phylogenetic swath of animal evolution. By consistently annotating and naming 10,899 microRNA genes in these organisms, we show that previous microRNA annotations contained not only many false positives, but surprisingly lacked >2000 bona fide microRNAs. Indeed, curated microRNA complements of closely related organisms are very similar and can be used to reconstruct ancestral miRNA repertoires. MirGeneDB represents a robust platform for microRNA-based research, providing deeper and more significant insights into the biology and evolution of miRNAs as well as biomedical and biomarker research.
Link to database: MirGeneDB
Read the full paper here.
Marc Friedländer has been awarded a VR research project grant for 4 years.