Internship in single-cell miRNA targeting and function
starting date as soon as possible, duration 3-4 month
Place: Stockholm University/SciLifeLab
Background: miRNAs are short non-coding RNAs around 22 nucleotides in length, which post-transcriptionally down-regulate gene expression. miRNAs guide the RNAi-induced silencing complex and bind to cognate mRNA targets in a sequence-specific manner. miRNA target identification is a challenging task, which relies on both experimental and extensive computational analyses. There currently does not exist any experimental techniques to identify miRNA targeting in single cells.
Goal: To assist in developing a new method to identify simultaneously miRNAs, their targets and the interaction between them in the single cells.
Requirements: We are looking for a student with a strong interest in RNA biology. Ideally, candidates have basic experience in laboratory methods used in molecular and cellular biology, biochemistry, and microscopy.